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a77636 hydrochloride  (Tocris)


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    Structured Review

    Tocris a77636 hydrochloride
    Figure 2. Effects of the D1-like receptor agonist <t>A77636</t> on nicotine and food intake and locomotor activity in male and female rats. The effects of A77636 on nicotine (A 15 min; B 24 h; C 48 h) and food intake (D 15 min; E 24 h; F 48 h) and locomotor activity (G 15 min; H 24 h; I 48 h) were investigated. Treatment with A77636 decreased nicotine intake 15 min, 24 h, and 48 h later. A77636 decreased food intake at the 15 min and 24 h time point and locomotor activity at the 48 h time point. Nicotine self-administration (males n = 9, females, n = 9), operant responding for food and small open field test (males n = 8, females, n = 8). Asterisks indicate a significant difference from rats of the same sex that received vehicle. *P < 0.05, **P < 0.01. Data are expressed as means ± SEM.
    A77636 Hydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 89/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/a77636 hydrochloride/product/Tocris
    Average 89 stars, based on 8 article reviews
    a77636 hydrochloride - by Bioz Stars, 2026-02
    89/100 stars

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    1) Product Images from "Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats."

    Article Title: Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats.

    Journal: Scientific reports

    doi: 10.1038/s41598-022-18081-3

    Figure 2. Effects of the D1-like receptor agonist A77636 on nicotine and food intake and locomotor activity in male and female rats. The effects of A77636 on nicotine (A 15 min; B 24 h; C 48 h) and food intake (D 15 min; E 24 h; F 48 h) and locomotor activity (G 15 min; H 24 h; I 48 h) were investigated. Treatment with A77636 decreased nicotine intake 15 min, 24 h, and 48 h later. A77636 decreased food intake at the 15 min and 24 h time point and locomotor activity at the 48 h time point. Nicotine self-administration (males n = 9, females, n = 9), operant responding for food and small open field test (males n = 8, females, n = 8). Asterisks indicate a significant difference from rats of the same sex that received vehicle. *P < 0.05, **P < 0.01. Data are expressed as means ± SEM.
    Figure Legend Snippet: Figure 2. Effects of the D1-like receptor agonist A77636 on nicotine and food intake and locomotor activity in male and female rats. The effects of A77636 on nicotine (A 15 min; B 24 h; C 48 h) and food intake (D 15 min; E 24 h; F 48 h) and locomotor activity (G 15 min; H 24 h; I 48 h) were investigated. Treatment with A77636 decreased nicotine intake 15 min, 24 h, and 48 h later. A77636 decreased food intake at the 15 min and 24 h time point and locomotor activity at the 48 h time point. Nicotine self-administration (males n = 9, females, n = 9), operant responding for food and small open field test (males n = 8, females, n = 8). Asterisks indicate a significant difference from rats of the same sex that received vehicle. *P < 0.05, **P < 0.01. Data are expressed as means ± SEM.

    Techniques Used: Activity Assay



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    Figure 2. Effects of the D1-like receptor agonist <t>A77636</t> on nicotine and food intake and locomotor activity in male and female rats. The effects of A77636 on nicotine (A 15 min; B 24 h; C 48 h) and food intake (D 15 min; E 24 h; F 48 h) and locomotor activity (G 15 min; H 24 h; I 48 h) were investigated. Treatment with A77636 decreased nicotine intake 15 min, 24 h, and 48 h later. A77636 decreased food intake at the 15 min and 24 h time point and locomotor activity at the 48 h time point. Nicotine self-administration (males n = 9, females, n = 9), operant responding for food and small open field test (males n = 8, females, n = 8). Asterisks indicate a significant difference from rats of the same sex that received vehicle. *P < 0.05, **P < 0.01. Data are expressed as means ± SEM.
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    Figure 2. Effects of the D1-like receptor agonist <t>A77636</t> on nicotine and food intake and locomotor activity in male and female rats. The effects of A77636 on nicotine (A 15 min; B 24 h; C 48 h) and food intake (D 15 min; E 24 h; F 48 h) and locomotor activity (G 15 min; H 24 h; I 48 h) were investigated. Treatment with A77636 decreased nicotine intake 15 min, 24 h, and 48 h later. A77636 decreased food intake at the 15 min and 24 h time point and locomotor activity at the 48 h time point. Nicotine self-administration (males n = 9, females, n = 9), operant responding for food and small open field test (males n = 8, females, n = 8). Asterisks indicate a significant difference from rats of the same sex that received vehicle. *P < 0.05, **P < 0.01. Data are expressed as means ± SEM.
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    Figure 2. Effects of the D1-like receptor agonist <t>A77636</t> on nicotine and food intake and locomotor activity in male and female rats. The effects of A77636 on nicotine (A 15 min; B 24 h; C 48 h) and food intake (D 15 min; E 24 h; F 48 h) and locomotor activity (G 15 min; H 24 h; I 48 h) were investigated. Treatment with A77636 decreased nicotine intake 15 min, 24 h, and 48 h later. A77636 decreased food intake at the 15 min and 24 h time point and locomotor activity at the 48 h time point. Nicotine self-administration (males n = 9, females, n = 9), operant responding for food and small open field test (males n = 8, females, n = 8). Asterisks indicate a significant difference from rats of the same sex that received vehicle. *P < 0.05, **P < 0.01. Data are expressed as means ± SEM.
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    Image Search Results


    Figure 2. Effects of the D1-like receptor agonist A77636 on nicotine and food intake and locomotor activity in male and female rats. The effects of A77636 on nicotine (A 15 min; B 24 h; C 48 h) and food intake (D 15 min; E 24 h; F 48 h) and locomotor activity (G 15 min; H 24 h; I 48 h) were investigated. Treatment with A77636 decreased nicotine intake 15 min, 24 h, and 48 h later. A77636 decreased food intake at the 15 min and 24 h time point and locomotor activity at the 48 h time point. Nicotine self-administration (males n = 9, females, n = 9), operant responding for food and small open field test (males n = 8, females, n = 8). Asterisks indicate a significant difference from rats of the same sex that received vehicle. *P < 0.05, **P < 0.01. Data are expressed as means ± SEM.

    Journal: Scientific reports

    Article Title: Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats.

    doi: 10.1038/s41598-022-18081-3

    Figure Lengend Snippet: Figure 2. Effects of the D1-like receptor agonist A77636 on nicotine and food intake and locomotor activity in male and female rats. The effects of A77636 on nicotine (A 15 min; B 24 h; C 48 h) and food intake (D 15 min; E 24 h; F 48 h) and locomotor activity (G 15 min; H 24 h; I 48 h) were investigated. Treatment with A77636 decreased nicotine intake 15 min, 24 h, and 48 h later. A77636 decreased food intake at the 15 min and 24 h time point and locomotor activity at the 48 h time point. Nicotine self-administration (males n = 9, females, n = 9), operant responding for food and small open field test (males n = 8, females, n = 8). Asterisks indicate a significant difference from rats of the same sex that received vehicle. *P < 0.05, **P < 0.01. Data are expressed as means ± SEM.

    Article Snippet: Drugs and treatment. (−)-Nicotine hydrogen tartrate (Sigma-Aldrich), SCH 23390 hydrochloride (Tocris bioscience), and A77636 hydrochloride (Tocris bioscience) were dissolved in sterile saline (0.9% sodium chloride).

    Techniques: Activity Assay